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Activation of Synovial Fluid T Lymphocytes by 60-Kd Heat-Shock Proteins in Patients with Inflammatory synovitis

✍ Scribed by Richard M. Pope; Rosa M. Lovis; Radhey S. Gupta


Publisher
John Wiley and Sons
Year
1992
Tongue
English
Weight
600 KB
Volume
35
Category
Article
ISSN
0004-3591

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Objective. To examine whether T cell reactivity toward heat-shock proteins (HSP) contributes to cartilage destruction in rheumatoid arthritis (RA). Methods. An in vitro system was used, in which human cartilage explants were cocultured with hsp60activated synovial fluid mononuclear cells (SFMC) fro