## Abstract Recent evidence has pointed to the mycobacterial 65‐kDa heat‐shock protein (hsp 65) as an antigen that may be important in the pathogenesis of rheumatoid arthritis (RA). Using limiting dilution analysis the frequency of purified protein derivative of tuberculin (PPD) and hsp 65‐responsi
Clonal expansion of mycobacterial heat-shock protein–reactive T lymphocytes in the synovial fluid and blood of rheumatoid arthritis patients
✍ Scribed by Linda Celis; Caroline Vandevyver; Piet Geusens; Jan Dequeker; Jef Raus; Jingwu Zhang
- Publisher
- John Wiley and Sons
- Year
- 1997
- Tongue
- English
- Weight
- 945 KB
- Volume
- 40
- Category
- Article
- ISSN
- 0004-3591
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## Abstract A commonly held postulate regarding the etiology of rheumatoid arthritis (RA) is that of antigenic mimicry. Recent interest has focused on the mycobacterial 65‐kDa heat‐shock protein (hsp) as a putative causal agent. The 65‐kDa hsp has over 40% sequence homology with the human hsp 60, a
In a previous study we have shown that synovial fluid mononuclear cells from many rheumatoid arthritis (RA) patients exhibit an enhanced response to M. tuberculosis antigens as compared to peripheral blood mononuclear cells. The 65-kDa heat-shock protein of M. tuberculosis was shown not to play an i