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Activation of repair and checkpoints by double-strand DNA breaks: Activational cascade of protein phosphorylation

โœ Scribed by N. A. Koltovaya


Book ID
110199676
Publisher
SP MAIK Nauka/Interperiodica
Year
2009
Tongue
English
Weight
255 KB
Volume
45
Category
Article
ISSN
1022-7954

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The initial step of the V(D)J recombination occurs through the generation of a DNA double-strand break (dsb). Defects in the DNA-dependent protein kinase complex (DNA-PK) result in an inability to perform either V(D)J recombination or any dsb repair effectively. The human autosomal T-B-severe combin