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Assessment of protein dynamics and DNA repair following generation of DNA double-strand breaks at defined genomic sites

โœ Scribed by Berkovich, Elijahu; Monnat, Raymond J; Kastan, Michael B


Book ID
109946612
Publisher
Nature Publishing Group
Year
2008
Tongue
English
Weight
189 KB
Volume
3
Category
Article
ISSN
1750-2799

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The initial step of the V(D)J recombination occurs through the generation of a DNA double-strand break (dsb). Defects in the DNA-dependent protein kinase complex (DNA-PK) result in an inability to perform either V(D)J recombination or any dsb repair effectively. The human autosomal T-B-severe combin