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Activation and regulation of ATM kinase activity in response to DNA double-strand breaks

โœ Scribed by Lee, J-H; Paull, T T


Book ID
110072857
Publisher
Nature Publishing Group
Year
2007
Tongue
English
Weight
212 KB
Volume
26
Category
Article
ISSN
0950-9232

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The initial step of the V(D)J recombination occurs through the generation of a DNA double-strand break (dsb). Defects in the DNA-dependent protein kinase complex (DNA-PK) result in an inability to perform either V(D)J recombination or any dsb repair effectively. The human autosomal T-B-severe combin