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Activation of p53 by the cytoprotective aminothiol WR1065: DNA-damage-independent pathway and redox-dependent modulation of p53 DNA-binding activity

✍ Scribed by Olivier Pluquet; Sophie North; Marie-Jeanne Richard; Pierre Hainaut

Book ID
113993402
Publisher
Elsevier Science
Year
2003
Tongue
English
Weight
439 KB
Volume
65
Category
Article
ISSN
0006-2952

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Restoration of wild-type conformation an
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## Abstract The aminothiol WR1065, the active metabolite of the cytoprotector amifostine, exerts its antimutagenic effects through free‐radical scavenging and other unknown mechanisms. In an earlier report, we showed that WR1065 activates wild‐type p53 in MCF‐7 cells, leading to p53‐dependent arres

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The transcription factor p53 controls the proliferation and survival of cells exposed to DNA damage. The specific DNA-binding domain of p53 (residues 102-292) has a complex tertiary structure that is stabilized by zinc. In this study, we showed that exposure of cultured cells to the membrane-permeab