Restoration of wild-type conformation an
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Sophie North; Olivier Pluquet; Daniela Maurici; Fatiha El Ghissassi; Pierre Hain
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Article
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2002
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John Wiley and Sons
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English
β 199 KB
## Abstract The aminothiol WR1065, the active metabolite of the cytoprotector amifostine, exerts its antimutagenic effects through freeβradical scavenging and other unknown mechanisms. In an earlier report, we showed that WR1065 activates wildβtype p53 in MCFβ7 cells, leading to p53βdependent arres