𝔖 Bobbio Scriptorium
✦   LIBER   ✦

The cytoprotective aminothiol WR1065 activates p21waf-1 and down regulates cell cycle progression through a p53-dependent pathway

✍ Scribed by North, S; El-Ghissassi, F; Pluquet, O; Verhaegh, G; Hainaut, P


Book ID
110062759
Publisher
Nature Publishing Group
Year
2000
Tongue
English
Weight
478 KB
Volume
19
Category
Article
ISSN
0950-9232

No coin nor oath required. For personal study only.


πŸ“œ SIMILAR VOLUMES


Restoration of wild-type conformation an
✍ Sophie North; Olivier Pluquet; Daniela Maurici; Fatiha El Ghissassi; Pierre Hain πŸ“‚ Article πŸ“… 2002 πŸ› John Wiley and Sons 🌐 English βš– 199 KB

## Abstract The aminothiol WR1065, the active metabolite of the cytoprotector amifostine, exerts its antimutagenic effects through free‐radical scavenging and other unknown mechanisms. In an earlier report, we showed that WR1065 activates wild‐type p53 in MCF‐7 cells, leading to p53‐dependent arres