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Activation of p21CIP1/WAF1 gene expression and inhibition of cell proliferation by overexpression of hepatocyte nuclear factor-4α

✍ Scribed by Hideki Chiba; Taisei Itoh; Seiro Satohisa; Naoyuki Sakai; Hiroko Noguchi; Makoto Osanai; Takashi Kojima; Norimasa Sawada


Book ID
118505926
Publisher
Elsevier Science
Year
2005
Tongue
English
Weight
603 KB
Volume
302
Category
Article
ISSN
0014-4827

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p21 WAF1/CIP1 is a downstream mediator of p53 and mediates growth arrest by inhibiting the action of G 1 cyclin-dependent kinases. Since cellular differentiation is frequently characterized by G 1 arrest, we examined whether p21 WAF1/CIP1 overexpression would induce growth suppression and differenti