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3.P.260 Tranilast inhibits cyclin-dependent kinase-2 and cyclin-dependent kinase-4 activity by expression of p21waf1/cip1

✍ Scribed by Takahashi, A.; Taniguchi, T.; Shimizu, H.; Yoshida, H.; Oda, A.; Kawasaki, S.; Ishikawa, Y.; Yokoyama, M.


Book ID
122051064
Publisher
Elsevier Science
Year
1997
Tongue
English
Weight
159 KB
Volume
134
Category
Article
ISSN
0021-9150

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WAF1/Cip1/Sdi1 (p21) is the prototype of a family of proteins that inhibit cyclin-dependent kinases and regulate cell cycle progression in eukaryotic cells. In addition to normal cell cycle progression, p21 is involved in growth suppression mediated by p53 and transforming growth factor beta (TGFbet