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p21Waf1 inhibits the activity of cyclin dependent Kinase 2 by preventing its activating phosphorylation

โœ Scribed by Hitomi, Masahiro; Shu, Junyan; Agarwal, Munna; Agarwal, Archana; Stacey, Dennis W


Book ID
110061492
Publisher
Nature Publishing Group
Year
1998
Tongue
English
Weight
457 KB
Volume
17
Category
Article
ISSN
0950-9232

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Human T-cell leukemia virus type 1 Tax a
โœ Iqbal H. Chowdhury; Arash Farhadi; Xiao-Fan Wang; Merlin L. Robb; Deborah L. Bir ๐Ÿ“‚ Article ๐Ÿ“… 2003 ๐Ÿ› John Wiley and Sons ๐ŸŒ French โš– 342 KB

We investigated the possible involvement of HTLV-1 Tax in the transcriptional activation of p21/Waf1/Cip1 (hereafter p21), a potent inhibitor of cyclin-dependent kinases and cell growth. Tax transfection resulted in enhanced expression of p21 protein in T and fibroblastoid cells. Similarly, Tax-expr