p19ARF prevents G1 cyclin-dependent kinase activation by interacting with MDM2 and activating p53 in mouse fibroblasts

Direct interaction with and activation o

Direct interaction with and activation of p53 by SMAR1 retards cell-cycle progression at G2/M phase and delays tumor growth in mice

✍ Ruchika Kaul; Sujoy Mukherjee; Farid Ahmed; Manoj Kumar Bhat; Rishiraj Chhipa; S 📂 Article 📅 2002 🏛 John Wiley and Sons 🌐 French ⚖ 873 KB

## Abstract The tumor‐suppressor p53 is a multifunctional protein mainly responsible for maintaining genomic integrity. p53 induces its tumor‐suppressor activity by either causing cell‐cycle arrest (G~1~/S or G~2~/M) or inducing cells to undergo apoptosis. This function of wild‐type p53 as “guardia