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Activation of AP-1 is required for bufalin-induced apoptosis in human leukemia U937 cells

✍ Scribed by Watabe, Masahiko; Ito, Kaori; Masuda, Yutaka; Nakajo, Shigeo; Nakaya, Kazuyasu

Book ID: 110061149
Publisher: Nature Publishing Group
Year: 1998
Tongue: English
Weight: 519 KB
Volume: 16
Category: Article
ISSN: 0950-9232
DOI: 10.1038/sj.onc.1201592

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## Abstract Nucleotides released from cells due to stress, injury or inflammation, induce mitogenic effects in monocytes via activation of P2Y~2~ nucleotide receptors (P2Y~2~Rs). Here we show that P2Y~2~ nucleotide receptors in U937 monocytic cells regulate the activation of extracellular signal‐re