Activation mechanisms of mafosfamide and the role of thiols in cyclophosphamide metabolism
โ Scribed by Kwon, Chul Hoon; Borch, Richard F.; Engel, Jurgen; Niemeyer, Ulf
- Book ID
- 126776642
- Publisher
- American Chemical Society
- Year
- 1987
- Tongue
- English
- Weight
- 588 KB
- Volume
- 30
- Category
- Article
- ISSN
- 0022-2623
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๐ SIMILAR VOLUMES
Cyclophosphamide (CPA), the most commonly used alkylating agent in the treatment of a wide variety of hematologic and solid tumors, requires oxidation by hepatic microsomal enzymes to its active alkylating species. A number of alternative methods exist to simulate the in vitro cytotoxicity of CPA ag
in hepatocytes, and that SEC glutathione (GSH) plays a ma-Hepatic venoocclusive disease (HVOD) is caused by jor role in detoxification. 10,11 Furthermore, the evidence sugthe disruption of the microcirculation by an as-yet ungests that profound depletion of SEC GSH might be the comknown mechanism. P