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Mechanism of Thioredoxin-Catalyzed Disulfide Reduction. Activation of the Buried Thiol and Role of the Variable Active-Site Residues

โœ Scribed by Carvalho, Alexandra T. P.; Swart, Marcel; van Stralen, Joost N. P.; Fernandes, Pedro A.; Ramos, Maria J.; Bickelhaupt, F. Matthias


Book ID
127054193
Publisher
American Chemical Society
Year
2008
Tongue
English
Weight
646 KB
Volume
112
Category
Article
ISSN
0022-3654

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Role of the variable active site residue
โœ Alexandra T. P. Carvalho; Pedro A. Fernandes; Marcel Swart; Joost N. P. Van Stra ๐Ÿ“‚ Article ๐Ÿ“… 2009 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 665 KB

## Abstract The enzymes of the thioredoxin family fulfill a wide range of physiological functions. Although they possess a similar CXYC active site motif, with identical environment and stereochemical properties, the redox potential and p__K__~a~ of the cysteine pair varies widely across the family