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Actinomycin D Binds to Metastable Hairpins in Single-Stranded DNA

✍ Scribed by Wadkins, Randy M.; Vladu, Bogdan; Tung, Chang-Shung


Book ID
126033881
Publisher
American Chemical Society
Year
1998
Tongue
English
Weight
161 KB
Volume
37
Category
Article
ISSN
0006-2960

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## Abstract Actinomycin D is an anticancer antibiotic best know for inhibiting transcription by binding double‐stranded DNA. Tight, sequence selective binding of actinomycin to single‐stranded DNA is also known, however, and is implicated in biological activities including inhibition of (βˆ’) strand