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Acrolein inactivates paraoxonase 1: changes in free acrolein levels after hemodialysis correlate with increases in paraoxonase 1 activity in chronic renal failure patients

✍ Scribed by Alejandro Gugliucci; Nicole Lunceford; Eriko Kinugasa; Hiroaki Ogata; John Schulze; Satoshi Kimura

Book ID: 116347670
Publisher: Elsevier Science
Year: 2007
Tongue: English
Weight: 714 KB
Volume: 384
Category: Article
ISSN: 0009-8981
DOI: 10.1016/j.cca.2007.06.012

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## Abstract **Background:** The mechanism of paraoxonase 1 (PON1) atheroprotective remains elusive. The lactonizing/lactonase activity of PON1 is gaining favor as the most significant in physiology. **Methods:** We studied 42 end-stage renal disease (ESRD) patients undergoing hemodialysis (HD) and