Acoustical damage to the rat brain

✍ Scribed by A.K. Singh; J. Behari; P. Raghunathan

• Book ID: 102631806
• Publisher: Elsevier Science
• Year: 1996
• Tongue: English
• Weight: 405 KB
• Volume: 48
• Category: Article
• ISSN: 0003-682X
• DOI: 10.1016/0003-682x(95)00051-a

✦ Synopsis

It has been concluded from the proton nuclear magnetic resonance spectrum of a sonicated rat brain that a peak recognized as lactate appears at 1.3 ppm; the same peak was absent in a normal brain spectrum. The cause of the appearance of this lactate peak was neuronal degradation: neuronal degradation leads to release of lactate. The reasons for the damage could be assigned to acoustical streaming produced by acoustical vibrations (4.0 W at 15.0 kHz). Gases dissolved in soft or hard tissue (skull) form bubbles which oscillate with their resonant frequency causing acoustic streaming and microstreaming. This streaming has produced neuronal damage, and hence the appearance of the lactate peak at 1.3 ppm.