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Rat model of perinatal hypoxic-ischemic brain damage

✍ Scribed by R.C. Vannucci; J.R. Connor; D.T. Mauger; C. Palmer; M.B. Smith; J. Towfighi; S.J. Vannucci

Publisher
John Wiley and Sons
Year
1999
Tongue
English
Weight
41 KB
Volume
55
Category
Article
ISSN
0360-4012

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✦ Synopsis

To gain insights into the pathogenesis and management of perinatal hypoxic-ischemic brain damage, the authors have used an immature rat model which they developed many years ago. The model entails ligation of one common carotid artery followed thereafter by systemic hypoxia. The insult produces permanent hypoxic-ischemic brain damage limited to the cerebral hemisphere ipsilateral to the carotid artery occlusion. The mini-review describes recently accomplished research pertaining to the use of the immature rat model, specifically, investigations involving energy metabolism, glucose transporter proteins, free radical injury, and seizures superimposed upon cerebral hypoxia-ischemia. Future research will focus on molecular mechanisms of neuronal injury with a continuing focus on therapeutic strategies to prevent or minimize hypoxic-ischemic brain damage.

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