To gain insights into the pathogenesis and management of perinatal hypoxic-ischemic brain damage, the authors have used an immature rat model which they developed many years ago. The model entails ligation of one common carotid artery followed thereafter by systemic hypoxia. The insult produces perm
Glucose, acidosis, and perinatal hypoxic-ischemic brain damage
β Scribed by Vannucci, Robert C. ;Vannucci, Susan J.
- Publisher
- John Wiley and Sons
- Year
- 1997
- Tongue
- English
- Weight
- 138 KB
- Volume
- 3
- Category
- Article
- ISSN
- 1080-4013
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β¦ Synopsis
This review describes the manner in which glucose or carbon dioxide protects the perinatal brain from hypoxic-ischemic damage.
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Neuroimaging has considerable potential for assessing the severity of brain damage in neonates who have suffered hypoxicischemic brain injury. This article reviews the recent literature concerning the concepts of perinatal hypoxic-ischemic brain injury as they relate to patterns of brain injury and
Vulnerability of neurotransmitter-specific neurons to hypoxia-ischemia was examined in the immature rat corpus striatum. Carotid artery ligation plus 2 hours of 896 oxygen atmosphere at 1 week of age produced ipsilateral striatal injury and reduced hemisphere mass 2 and 6 weeks later. Striatal injur