The lipase-eatalyzed asymmetrization of the prochiral 2,2-disubstituted 1,3-propanediois 1, 6, and 9 was studied using various types of l-ethoxyvinyl esters 2. Among them, the use of the benzoate 2f provided good chemical and optical yields of the products 3, 7, and 10 bearing chiral quaternary carb
Acid catalyzed racemization of 1-(heterocyclyloxy)-2,3-propanediols
โ Scribed by Barlow, Jeffrey J.; Block, Michael H.; Hudson, Julian A.; Leach, Alison; Longridge, Jethro L.; Main, Brian G.; Nicholson, Stuart
- Book ID
- 126064213
- Publisher
- American Chemical Society
- Year
- 1992
- Tongue
- English
- Weight
- 611 KB
- Volume
- 57
- Category
- Article
- ISSN
- 0022-3263
No coin nor oath required. For personal study only.
๐ SIMILAR VOLUMES
Enzyme-Catalyzed Asymmetrization of 2,2-Disubstituted 1,3-Propanediols Using 1-Ethoxyvinyl Esters. -The lipase-mediated asymmetrization of prochiral diols using various 1-ethoxyvinyl esters (I) is studied. The benzoate ester (Ia) provides good to excellent chemical yields and the highest enantiosel
A new strategy for racemization of the 2-amino-l ,3-propanediol 2&, based on a chemoselective oxazoline ring formation and a highly diastereoselective reduction of the ketone 2 is reported. Thiamphenicol 1,' threo-(1R,2R)-2-dichloroacetamido-l-(4-me~hylsulfonyl)-l ,3-propanediol, possesses a fairly