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Acetylator Genotype-Dependent Formation of 2-Aminofluorene-Hemoglobin Adducts in Rapid and Slow Acetylator Syrian Hamsters Congenic at the NAT2 Locus

✍ Scribed by Y. Feng; T.D. Rustan; R.J. Ferguson; M.A. Doll; D.W. Hein


Book ID
112265613
Publisher
Elsevier Science
Year
1994
Tongue
English
Weight
611 KB
Volume
124
Category
Article
ISSN
0041-008X

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Tissue distribution of N-acetyltransfera
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## Abstract __N__‐acetyltransferase 1 (NAT1) and 2 (NAT2) enzymes catalyzing both deactivation (__N__‐acetylation) and activation (__O__‐acetylation) of arylamine carcinogens such as 4‐aminobiphenyl (ABP) were investigated in a Syrian hamster model congenic at the __NAT__2 locus. NAT2 catalytic act