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Construction of Syrian Hamster Lines Congenic at the Polymorphic Acetyltransferase Locus (NAT2): Acetylator Genotype-Dependent N- and O-Acetylation of Arylamine Carcinogens

✍ Scribed by D.W. Hein; M.A. Doll; T.D. Rustan; K. Gray; R.J. Ferguson; Y. Feng

Book ID: 112265614
Publisher: Elsevier Science
Year: 1994
Tongue: English
Weight: 868 KB
Volume: 124
Category: Article
ISSN: 0041-008X
DOI: 10.1006/taap.1994.1003

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## Abstract __N__‐acetyltransferase 1 (NAT1) and 2 (NAT2) enzymes catalyzing both deactivation (__N__‐acetylation) and activation (__O__‐acetylation) of arylamine carcinogens such as 4‐aminobiphenyl (ABP) were investigated in a Syrian hamster model congenic at the __NAT__2 locus. NAT2 catalytic act