The retinoblastoma protein (pRB) can both positively and negatively regulate transcription. The former correlates with its ability to promote differentiation and the latter with its ability to regulate entry into S-phase. pRB negatively regulates transcription by forming complexes with members of th
Acetylation regulates the differentiation-specific functions of the retinoblastoma protein
โ Scribed by Nguyen, Don X; Baglia, Laurel A; Huang, Shih-Min; Baker, Christina M; McCance, Dennis J
- Book ID
- 110027590
- Publisher
- Nature Publishing Group
- Year
- 2004
- Tongue
- English
- Weight
- 279 KB
- Volume
- 23
- Category
- Article
- ISSN
- 0261-4189
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The product of the retinoblastoma gene ( R B I ) is believed to function as a negative regulator of cell growth. Recent experimental results suggest that RBI may exert its growth-suppressing activity by regulating the transcription of a variety of growthrelated genes, including FOS, MYC, and TGFB /.
## Abstract The retinoblastoma protein (pRb105) is a true tumor suppressor as deregulation of the Rb pathway by either mutation of pRb105 itself or other proteins in the pathway, such as p16INK4a, occur in most cancers. This prototypical family member, along with the related p107 and p130, are invo