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Acetylation of 5-aminosalicylate by hamster colon arylamine N-acetyltransferase

✍ Scribed by Mark A. Tucker; Timothy J. Smith

Book ID: 102289321
Publisher: John Wiley and Sons
Year: 1990
Tongue: English
Weight: 133 KB
Volume: 10
Category: Article
ISSN: 0260-437X
DOI: 10.1002/jat.2550100114

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✦ Synopsis

Recent evidence suggests that 5-aminosalicylate acts as an anti-inflammatory agent by virtue of its ability to act as a free-radical scavenger. The major metabolite, N-acetyl-5-aminosalicylate is not an effective freeradical scavenger. We have demonstrated that an arylamine N-acetyltransferase from hamster colon can directly acetylate 5-aminosalicylate, suggesting that the colon may have the ability to modulate the activity of this agent through metabolic inactivation.

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