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Mass Spectrometric Investigation of the Mechanism of Inactivation of Hamster Arylamine N-Acetyltransferase 1 by N-Hydroxy-2-Acetylaminofluorene

✍ Scribed by Guo, Zhijun; Wagner, Carston R.; Hanna, Patrick E.

Book ID: 127291042
Publisher: American Chemical Society
Year: 2004
Tongue: English
Weight: 179 KB
Volume: 17
Category: Article
ISSN: 0893-228X
DOI: 10.1021/tx030045o

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## Abstract __N__‐acetyltransferase 1 (NAT1) and 2 (NAT2) enzymes catalyzing both deactivation (__N__‐acetylation) and activation (__O__‐acetylation) of arylamine carcinogens such as 4‐aminobiphenyl (ABP) were investigated in a Syrian hamster model congenic at the __NAT__2 locus. NAT2 catalytic act