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Irreversible Inactivation of Arylamine N-Acetyltransferases in the Presence of N-Hydroxy-4-Acetylaminobiphenyl: A Comparison of Human and Hamster Enzymes

โœ Scribed by Wang, Haiqing; Wagner, Carston R.; Hanna, Patrick E.


Book ID
127165898
Publisher
American Chemical Society
Year
2005
Tongue
English
Weight
433 KB
Volume
18
Category
Article
ISSN
0893-228X

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## Abstract __N__โ€acetyltransferase 1 (NAT1) and 2 (NAT2) enzymes catalyzing both deactivation (__N__โ€acetylation) and activation (__O__โ€acetylation) of arylamine carcinogens such as 4โ€aminobiphenyl (ABP) were investigated in a Syrian hamster model congenic at the __NAT__2 locus. NAT2 catalytic act