✦ LIBER ✦

Acetaminophen-induced fulminant hepatic failure in Dogs

✍ Scribed by L. Ortega; J. I. Landa Garcia; A. Torres Garcia; G. Silecchia; J. Arenas; A. Suarez; M. Moreno Azcoitia; J. Sanz Esponera; E. Moreno Gonzalez; J. L. Balibrea Cantero

Publisher: John Wiley and Sons
Year: 1985
Tongue: English
Weight: 516 KB
Volume: 5
Category: Article
ISSN: 0270-9139
DOI: 10.1002/hep.1840050425

No coin nor oath required. For personal study only.

✦ Synopsis

Results concerning morphological and biochemical changes following intravenous administration of different doses of acetaminophen in dogs are reported. Acetaminophen infusion, as a parenteral solution (500 mg per kg per 90 min), produced fulminant hepatitis characterized by a good correlation between Portmann's grade of lesion and percentage of necrosis. All animals died within 76 hr after intoxication. Analysis of biochemical parameters revealed positive correlation between serum bilirubin levels and severity of the hepatic lesion. The experimental model of acetaminophen-induced hepatotoxicity is proposed as a model for evaluation of the therapeutic efficacy of new medical and surgical procedures.

📜 SIMILAR VOLUMES

An improved model of acetaminophen-induc

An improved model of acetaminophen-induced fulminant hepatic failure in dogs

✍ James H. Kelly; Tarek Koussayer; Da-Er He; Maria G. Chong; Thomas A. Shang; Hart 📂 Article 📅 1992 🏛 John Wiley and Sons 🌐 English ⚖ 920 KB

We have established an improved model of fulminant hepatic failure in dogs. Buthionine sulfoximine is used to inactivate glutathione synthesis, and small increments of acetaminophen are given intravenously to maintain the plasma level at approximately 200 pg/ml for 20 hr. This regimen produces sever

Galactosamine-induced fulminant hepatic

Galactosamine-induced fulminant hepatic failure

✍ S L Nyberg 📂 Article 📅 1997 🏛 John Wiley and Sons 🌐 English ⚖ 139 KB

Histopathological heterogeneity in fulmi

Histopathological heterogeneity in fulminant hepatic failure

✍ Cheryl Hanau; Santiago J. Munoz; Raphael Rubin 📂 Article 📅 1995 🏛 John Wiley and Sons 🌐 English ⚖ 1011 KB

The clinicopathological features of 38 patients admitted consecutively for fulminant hepatic failure were studied. Histopathological material was reviewed in all patients. Both percutaneous and whole livers (either explanted or autopsy specimens) were available in 16 patients: whole livers only in 1

Posttransplantation chronic hepatitis in

Posttransplantation chronic hepatitis in fulminant hepatic failure

✍ R Mohamed; S G Hubscher; D F Mirza; B K Gunson; D J Mutimer 📂 Article 📅 1997 🏛 John Wiley and Sons 🌐 English ⚖ 942 KB

The incidence of chronic hepatitis in the overall liver trans-Specimens were processed routinely into paraffin blocks and stained with the following: hematoxylin and eosin, hematoxylin van Gieson, reticulin, orcein, Perl's reaction, and periodic acid Schiff with and without diastase pretreatment. Sp

Matrix metalloproteinase-9 in fulminant

Matrix metalloproteinase-9 in fulminant hepatic failure

✍ Lluis Palenzuela; Antoni Mas; Joan Montaner; Juan Cordoba 📂 Article 📅 2010 🏛 John Wiley and Sons 🌐 English ⚖ 304 KB

After reading the article by Taura et al. with great interest, we really appreciate the ingenious work they have done. 1 In this study, they found type I collagen-producing cells do not originate from hepatocytes in a triple transgenic mouse model. Hepatocytes in vivo neither express mesenchymal mar

Hepatocyte growth factor in fulminant he

Hepatocyte growth factor in fulminant hepatic failure

✍ Robin D. Hughes; Christopher D. Gove; Roger Williams; Hirohita Tsubouchi; Yasush 📂 Article 📅 1990 🏛 John Wiley and Sons 🌐 English ⚖ 248 KB

We read with great interest the paper by Tsubouchi et al. (1) on the hepatocyte growth factor (hHGF) in the blood of patients with fulminant hepatic failure (FHF). These authors have already elegantly reported the purification and partial characterization of hHGF from the plasma of a patient with FH