## Abstract This study was designed to investigate the influence of 2βmethylβ6βphenylethynyl pyridine hydrochloride (MPEP), an antagonist of metabotropic glutamate receptor subtype 5, in lipopolysaccharide (LPS) and dβgalactosamine (dβGalN)βinduced fulminant hepatic failure in mice. Mice were given
Galactosamine-induced fulminant hepatic failure
β Scribed by S L Nyberg
- Publisher
- John Wiley and Sons
- Year
- 1997
- Tongue
- English
- Weight
- 139 KB
- Volume
- 26
- Category
- Article
- ISSN
- 0270-9139
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Abbreviations: FHF, fulminant hepatic failure; IV, intravenous; AST, aspartate transtaneous cannulation with polyurethane single lumen catheters (Medaminase; ALT, alanine transaminase; PT, prothrombin time; PTT, partial thromboplastin time. Comp MCF10, Harleysville, PA), using the Seldinger techniq
Background. When administered early after an overdose of acetaminophen, intravenous acetylcysteine prevents hepatic necrosis by replenishing reduced stores of glutathione. How acetylcysteine improves the survival of patients with established liver damage induced by acetaminophen, however, is unknown
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