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Accumulation of glucocorticoids in regenerating areas of limbs of the newt,Notophthalmus viridescens

✍ Scribed by Bromley, Stephen C

Publisher: John Wiley and Sons
Year: 1977
Tongue: English
Weight: 854 KB
Volume: 201
Category: Article
ISSN: 0022-104X
DOI: 10.1002/jez.1402010112

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✦ Synopsis

Abstract

Evidence is presented that regenerating portions of newt limbs preferentially accumulate ^3^H‐labelled exogeneous cortisol and corticosterone. The ability of such regions to accumulate glucocorticoids is maximal about seven days after amputation and is abolished by interrupting the spinal nerves innervating the limb. Either hypophysectomy or ablation of interrenal tissue is without marked effect. The accumulation effect is not shown by aldosterone, testosterone, glucose, cholesterol, or leucine but estradiol does accumulate to a some‐what lesser extent than do the glucocorticoids examined.

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