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Cyclophosphamide-induced leukopenia and suppression of limb regeneration in the adult newt,Notophthalmus viridescens

✍ Scribed by Schotté, Oscar E. ;Sicard, Raymond E.

Publisher
John Wiley and Sons
Year
1982
Tongue
English
Weight
307 KB
Volume
222
Category
Article
ISSN
0022-104X

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✦ Synopsis

Abstract

Cyclophosphamide (cytoxan), a clinical immunosuppressant, produced a marked, persistent leukopenia (> 40% reduction) in adult newts in contrast to a transient, milder leukopenia accompanying amputations without cytoxan treatments. In addition, cytoxan suppressed the formation of regeneration blastemata initially; however, blastema formation occurred if a second amputation was performed two or more weeks following the cessation of cytoxan treatments. The failure of the leukopenias of these latter cases to be corrected suggests that although a cytoxan‐induced leukopenia is correlated with the absence of forelimb regeneration, this leukopenia is not, of itself, a sufficient condition to inhibit regeneration.

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