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Accounting for plating efficiency when estimating spontaneous mutation rates

✍ Scribed by Michael E. Jones

Book ID
113252935
Publisher
Elsevier Science
Year
1993
Tongue
English
Weight
146 KB
Volume
292
Category
Article
ISSN
0165-1161

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An algorithm accounting for plating effi
An algorithm accounting for plating efficiency in estimating spontaneous mutation rates
✍ Michael E. Jones πŸ“‚ Article πŸ“… 1993 πŸ› Elsevier Science 🌐 English βš– 569 KB

An algorithm is described for calculating the probability distribution of the number of mutant colonies arising in a Luria-Delbrtick fluctuation experiment subject to a plating efficiency of less than 100%. A table is constructed to facilitate the estimation of spontaneous mutation rates taking into

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Mutations and infinity: Improved statistical methods for estimating spontaneous rates
✍ Arthur NΓ‘das; Ekaterina I. Goncharova; Toby G. Rossman πŸ“‚ Article πŸ“… 1996 πŸ› John Wiley and Sons 🌐 English βš– 864 KB

Certain mathematical artifacts which had been a p pended by others to Luria and Delbruck's [Genetics 28: 491 -5 1 1, 19431 model of spontaneous mutagenesis in bacterial populations have added confusion to the modeling and measurement of spontaneous mutation rates. Additional confusion arises when mo

Luria-DelbrΓΌck Fluctuation Experiments;
Luria-DelbrΓΌck Fluctuation Experiments; Accounting Simultaneously for Plating Efficiency and Differential Growth Rate
✍ M.E. Jones πŸ“‚ Article πŸ“… 1994 πŸ› Elsevier Science 🌐 English βš– 368 KB

Cells growing in culture are subject to mutation, and as mutation is a random event, the number of mutants in a culture will be a random variable. The size of the clone of mutants arising from a single mutational event depends on the timing of the mutation; the earlier the mutation the larger the co