𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Accelerated Caco-2 cell permeability model for drug discovery

✍ Scribed by Sevin, E.; Dehouck, L.; Fabulas-da Costa, A.; Cecchelli, R.; Dehouck, M.P.; Lundquist, S.; Culot, M.

Book ID
121678715
Publisher
Elsevier Science
Year
2013
Tongue
English
Weight
718 KB
Volume
68
Category
Article
ISSN
1056-8719

No coin nor oath required. For personal study only.

πŸ“œ SIMILAR VOLUMES

Coumarins permeability in Caco-2 cell mo
Coumarins permeability in Caco-2 cell model
✍ Anna Galkin; Adyary Fallarero; Professor Pia M. Vuorela πŸ“‚ Article πŸ“… 2009 πŸ› Pharmaceutical Press 🌐 English βš– 234 KB
Combined application of parallel artific
Combined application of parallel artificial membrane permeability assay and Caco-2 permeability assays in drug discovery
✍ Edward H. Kerns; Li Di; Susan Petusky; Michele Farris; Rob Ley; Phil Jupp πŸ“‚ Article πŸ“… 2004 πŸ› John Wiley and Sons 🌐 English βš– 296 KB

Data from permeability profiling using the parallel artificial membrane permeability assay (PAMPA) and cell monolayer (Caco-2 and MDR1-MDCKII) methods were compared for two published compound sets and one in-house set. A majority of compounds in each set correlated (R 2 ΒΌ 0.76-0.92), indicating the

Simulation modelling of human intestinal
Simulation modelling of human intestinal absorption using Caco-2 permeability and kinetic solubility data for early drug discovery
✍ Simon Thomas; Frances Brightman; Helen Gill; Sally Lee; Boris Pufong πŸ“‚ Article πŸ“… 2008 πŸ› John Wiley and Sons 🌐 English βš– 218 KB

Measurement of permeation across a monolayer of the human adenocarcinoma cell line, Caco-2, is a popular surrogate for a compound's permeation across the human intestinal epithelium. Taken alone, however, Caco-2 permeability has certain limitations in the prediction of the extent of absorption of an