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Optimized conditions for prediction of intestinal drug permeability using Caco-2 cells

โœ Scribed by Shinji Yamashita; Tomoyuki Furubayashi; Makoto Kataoka; Toshiyasu Sakane; Hitoshi Sezaki; Hideaki Tokuda

Book ID
114301727
Publisher
Elsevier Science
Year
2000
Tongue
English
Weight
276 KB
Volume
10
Category
Article
ISSN
0928-0987

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Measurement of permeation across a monolayer of the human adenocarcinoma cell line, Caco-2, is a popular surrogate for a compound's permeation across the human intestinal epithelium. Taken alone, however, Caco-2 permeability has certain limitations in the prediction of the extent of absorption of an