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Absorption, distribution and excretion of 14C-meglumine in rats and dogs after administration of 14C-meglumine salicylate

✍ Scribed by Joel F. Heeg; Gordon S. Born; Wayne V. Kessler; Stanley M. Shaw; Winthrop E. Lange

Publisher
John Wiley and Sons
Year
1977
Tongue
English
Weight
526 KB
Volume
66
Category
Article
ISSN
0022-3549

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✦ Synopsis

Meglumine labeled with carbon-14 was administered orally as 14C-meglumine salicylate to rats and dogs to study its distribution and excretion. The compound was incompletely absorbed; that which was absorbed was rapidly excreted in the urine. Peak blood levels were about 5-10 mug/ml in rats and 2-8 mug/ml in dogs. Tissue levels were negligible at the end of the experimental periods. No evidence for N-demethylation or oxidation to carbon dioxide was obtained.

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