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Urinary excretion products after the administration of 14C-acetaldehyde to rats

✍ Scribed by Seija Kallama; Kari Hemminki

Publisher
John Wiley and Sons
Year
1983
Tongue
English
Weight
380 KB
Volume
3
Category
Article
ISSN
0260-437X

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✦ Synopsis

Abstract

Rats were injected with 120 μCi of ^14^C‐acetaldehyde containing carrier acetaldehyde, and the urinary excretion products were assayed by cation exchange chromatography, resolving five main peaks of radioactivity. Urine contained 6% of the dose of ^14^C‐acetaldehyde administered. The main urinary product of acetaldehyde, fraction 5, was produced via acetate. Acetate was also identified in the urine. Two cysteine adducts, probably isomeric metabolites of 2‐methylthiazolidine‐4‐carboxylic acid, were detected. They constituted about 2% of the radioactivity in the urine collected 48 h after the administration of ^14^C‐acetaldehyde. They appeared to retain a carboxylic group. When the reaction mixture of ^14^C‐cysteine and acetaldehyde was injected into a rat, the half‐lives of the two tiazolidine derivatives was 10 h. Only 13.6% of the radioactivity was detected in the urine suggesting ready metabolism of 2‐methylthiazolidine‐4‐carboxylic acid.

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