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Urinary cyclophosphamide excretion in rats after intratracheal, dermal, oral and intravenous administration of cyclophosphamide

✍ Scribed by P. J. M. Sessink; P. H. H. van den Broek; R. P. Bos

Publisher
John Wiley and Sons
Year
1991
Tongue
English
Weight
344 KB
Volume
11
Category
Article
ISSN
0260-437X

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✦ Synopsis

Abstract

The urinary excretion of unmetabolized cyclophosphamide was studied in rats after intratracheal, dermal, oral and intravenous administration. Rats were given two doses of 1 mg kg^βˆ’1^ cyclophosphamide 48 h apart and urine was collected for 96 h after the first treatment.

With the help of a phosphor‐specific filter in a flame photometer attached to a gas chromatograph, low levels of cyclophosphamide were determined after derivatization with trifluoroacetic anhydride.

Cumulative excretion as a percentage of dose ranged from 4.0 to 6.9 after the first dose and 2.7 to 5.5 after the second dose. The highest rate of excretion after the second administration was observed in rats treated intratracheally, while cumulative excretion was higher (6.9%) after the first than after the second (2.7%) intravenous treatment. The most prolonged excretion was observed after dermal application.

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