Absorption and excretion of riboflavin in the rat: An unusual example of nonlinear pharmacokinetics
β Scribed by James E. Axelson; Milo Gibaldi
- Publisher
- John Wiley and Sons
- Year
- 1972
- Tongue
- English
- Weight
- 450 KB
- Volume
- 61
- Category
- Article
- ISSN
- 0022-3549
No coin nor oath required. For personal study only.
π SIMILAR VOLUMES
The pharmacokinetics of pafenolol, a highly selective /?,-adrenoceptor antagonist, have been studied in starved and unstarved rats. Separate groups received intravenous doses (0.3 and 3.0pmol kg-I) and oral doses (1 and 25pmol kg-I). The systemic clearance of pafenolol was constant in the dose range
Sotalol (STL) is an amphoteric, chiral p-adrenergic blocking drug useful in the treatment of both hypertension and ventricular arrhythmias. In the human and rat, STL enantiomers are predominantly cleared from the body by the kidney as intact drug. The renal clearance (a,) of STL enantiomers substant