Absorption, metabolism, and excretion of the ephedrines in man II. Pharmacokinetics
β Scribed by G. R. Wilkinson; A. H. Beckett
- Publisher
- John Wiley and Sons
- Year
- 1968
- Tongue
- English
- Weight
- 514 KB
- Volume
- 57
- Category
- Article
- ISSN
- 0022-3549
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π SIMILAR VOLUMES
a two-step protonation. As a check of the method, the pKa of o-iodobenzoic acid was determined concurrently, yielding the value of -7.4 which is in good agreement with previously published data ( 12). A first protonation of compound I could lead to structures Ib, Id, Ic, or If; loss of water from I
Hydroxylation is the predominant pathway of metabolism for sulfatroxazole in the body, accounting for 70 per cent of the dose. Fifteen per cent of the dose is acetylated unimodally and 10 per cent is excreted unchanged. The half-lives of sulfatroxazole and its metabolites 5-hydroxysulfatroxazole and
## Abstract Three healthy male subjects received single 100mg oral doses of carprofen containing 20 ΞΌCi of ^14^Cβcarprofen. Venous blood samples were drawn during the first 48 h after the dose and urine and feces were collected for 120h. Concentrations of carprofen and its metabolites in body fluid
35S-Furosemide was administered to beagle dogs and rhesus monkeys in an oral solution on a single and a 20 repeated 5-mg/kg/day dosing regimen. Following the single dose, 25.0% (dogs) and 24.0% (monkeys) of the dose were excreted in the urine in 24 hr. TLC analysis demonstrated that both species had