Absolute configuration of (I) (–)-(3S,4R)- and (II) (–)-(3S,4S)-3-methyl-4-phenyl-4-piperidinecarboxylic acid hydrobromide
✍ Scribed by Peeters, O. M. ;Blaton, N. M. ;De Ranter, C. J.
- Book ID
- 114510785
- Publisher
- International Union of Crystallography
- Year
- 1994
- Tongue
- English
- Weight
- 297 KB
- Volume
- 50
- Category
- Article
- ISSN
- 0108-2701
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The title compound, C 19 H 22 N + ÁI À , is a new dihydroisoquinolinium salt, used as a catalyst in asymmetric epoxidation. It was characterized by NMR spectroscopy and X-ray crystallographic techniques. The absolute configurations of the two stereogenic centres were established by the refinement of
At 173 K, the ®ve-membered ring of the title compound, C 22 H 26 N 2 O 5 , has an envelope conformation. The amine group is involved in both intramolecular and intermolecular hydrogen bonds, the latter linking the molecules into centrosymmetric dimers. ## Experimental The title compound was prepa