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Structure and absolute configuration of (3S)-[(1S,2R,4S)-2-acetoxy-4-methyl-1-cyclohexyl]-2,2-dichloro-3-methylcyclobutanone

✍ Scribed by Zukerman-Schpector, J. ;Castellano, E. E. ;Brocksom, T. J. ;Moreira, L. A.


Book ID
114508699
Publisher
International Union of Crystallography
Year
1991
Tongue
English
Weight
317 KB
Volume
47
Category
Article
ISSN
0108-2701

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Stereoselective synthesis of (1β€²S,3R,4R)
✍ Ivan Plantan; Michel Stephan; UroΕ‘ Urleb; Barbara Mohar πŸ“‚ Article πŸ“… 2009 πŸ› Elsevier Science 🌐 French βš– 218 KB

A stereoselective synthesis of (1 0 S,3R,4R)-4-acetoxy-3-(2 0 -fluoro-1 0 -trimethylsilyloxyethyl)-2-azetidinone as a new fluorine-containing intermediate towards b-lactams, is described. The synthetic key step relies upon the dynamic kinetic resolution (DKR) of ethyl 2-benzamidomethyl-4-fluoro-3-ox