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Absence seizures are reduced by the enhancement of GABA-ergic inhibition in the hippocampus in WAG/Rij rats

โœ Scribed by Elena A. Tolmacheva; Gilles van Luijtelaar


Book ID
116769356
Publisher
Elsevier Science
Year
2007
Tongue
English
Weight
298 KB
Volume
416
Category
Article
ISSN
0304-3940

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CNQX, a new non-NMDA receptor antagonist
โœ G.M.J. Ramakers; B.W.M.M. Peeters; J.M.H. Vossen; A.M.L. Coenen ๐Ÿ“‚ Article ๐Ÿ“… 1991 ๐Ÿ› Elsevier Science ๐ŸŒ English โš– 330 KB

The effects on seizures, EEG and behavior of the non-NMDA receptor antagonist CNQX (6-cyano-7-nitroquinoxaline-2,3-dione), were studied in the WAG/Rij rat with absence epilepsy. Intracerebroventricular injections (10, 50, and 100 nmol/5 microliters CNQX) showed that CNQX decreases the number of spik