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Absence of mutations in the ATM gene in breast cancer patients with severe responses to radiotherapy

✍ Scribed by Appleby, JM; Barber, JBP; Levine, E; Varley, JM; Taylor, AMR; Stankovic, T; Heighway, J; Warren, C; Scott, D


Book ID
109837469
Publisher
Nature Publishing Group
Year
1997
Tongue
English
Weight
638 KB
Volume
76
Category
Article
ISSN
0007-0920

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Association of two mutations in the CHEK
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## Abstract The 1100delC mutation of the cell cycle checkpoint kinase 2 (__CHEK2__) gene confers an increased risk for breast cancer, but the clinical impact of other __CHEK2__ gene variants remains unclear. We determined the frequency of two functionally relevant __CHEK2__ gene mutations, I157T an