Absence of mutations in the ATM gene in forty-seven cases of sporadic breast cancer
β Scribed by Bebb, D G; Yu, Z; Chen, J; Telatar, M; Gelmon, K; Phillips, N; Gatti, R A; Glickman, B W
- Book ID
- 110002417
- Publisher
- Nature Publishing Group
- Year
- 1999
- Tongue
- English
- Weight
- 49 KB
- Volume
- 80
- Category
- Article
- ISSN
- 0007-0920
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π SIMILAR VOLUMES
The gene mutated in ataxia telangiectasia (A-T) patients (ATM) is located on chromosome 11q22-23, a region frequently altered in mammary tumors. Patients homozygous for ATM mutations are prone to develop a variety of different neoplasms. Female heterozygotes have been reported to carry a 5-to 8-fold
## Abstract It has been proposed that women carrying heterozygous mutations of the __ATM__ gene could be at increased risk of developing breast cancer. However, data in the literature are contrasting and no firm conclusion has been reached. Our aim was to verify whether __ATM__ inactivation could p