Absence of Detectable P450 2E1 in Bone Marrow of B6C3F1 Mice: Relevance to Butadiene-Induced Bone Marrow Toxicity
โ Scribed by Mary Beth Genter; Leslie Recio
- Book ID
- 115608309
- Publisher
- Elsevier Science
- Year
- 1994
- Tongue
- English
- Weight
- 710 KB
- Volume
- 22
- Category
- Article
- ISSN
- 0272-0590
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๐ SIMILAR VOLUMES
W e have examined the spectra of mutations in a collection of 7 4 lac1 mutants isolated from the bone marrow of B6C3F1 lac1 transgenic mice exposed to 1,250 ppm 1,3-butadiene (BD). Of the 49 inde pendent mutations analyzed in the present study, 30 of 49 (61 %) were point mutations at G:C base pairs,
Carolina 1,3-Butadiene (BD) is a carcinogen that is bioactivated to at least two genotoxic metabolites. In the present article, we review briefly our previous studies on the in vivo mutagenicity and mutational spectra of BD in bone marrow and extend these studies to examine the effect of exposure ti