Benzene increases protein-bound 3-nitrotyrosine in bone marrow of B6C3F1 mice
โ Scribed by Kun-Ming Chen; Karam El-Bayoumy; James Hosey; John Cunningham; Cesar Aliaga; Assieh A. Melikian
- Book ID
- 113517191
- Publisher
- Elsevier Science
- Year
- 2005
- Tongue
- English
- Weight
- 208 KB
- Volume
- 156
- Category
- Article
- ISSN
- 0009-2797
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W e have examined the spectra of mutations in a collection of 7 4 lac1 mutants isolated from the bone marrow of B6C3F1 lac1 transgenic mice exposed to 1,250 ppm 1,3-butadiene (BD). Of the 49 inde pendent mutations analyzed in the present study, 30 of 49 (61 %) were point mutations at G:C base pairs,
## Abstract The oral and i.v. elimination kinetics were investigated for bromodichloroacetate (BDCA), a haloacetate found in drinking water. The BDCA was administered at a dose of 5, 20 and 100 mg kg^โ1^ to B6C3F1 mice and appears to distribute to the total body water with a mean volume of distribu