Clinical trials with the hexitol derivat
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Delia F. Chiuten; Marcel Rozencweig; Daniel D. von Hoff; Franco M. Muggia
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Article
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1981
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John Wiley and Sons
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English
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Three hexitol derivatives, dibromomannitol (DBM), dibromodulcitol (DBD), and dianhydrogalactitol (DAG), originally investigated in Hungary, have been evaluated as anticancer agents in the United States. Their principal mechanism of action is attributed to alkylation via actual or derived epoxide gro