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Hepatoxicity in the U.S. Adult AIDS Clinical Trial Group

โœ Scribed by Julie C. Servoss; Kenneth E. Sherman; Gregory Robbins; Song-Heng Liou; Ronald Reisler; Bruce Polsky; Robert Murphy; Dickens Theodore; Emil Miskovsky; Raymond T. Chung


Book ID
119429131
Publisher
Elsevier Science
Year
2001
Tongue
English
Weight
188 KB
Volume
120
Category
Article
ISSN
0016-5085

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Three hexitol derivatives, dibromomannitol (DBM), dibromodulcitol (DBD), and dianhydrogalactitol (DAG), originally investigated in Hungary, have been evaluated as anticancer agents in the United States. Their principal mechanism of action is attributed to alkylation via actual or derived epoxide gro