## Abstract Cytogenetic studies of eight meningiomas in young children or adolescents were performed. Two tumors exhibited normal karyotypes. Two tumors from patients with bilateral acoustic neurofibromatosis demonstrated monosomy 22 as the only abnormality. Four patients had more complicated karyo
Abnormalities of chromosome 22 in meningiomas and confirmation of the origin of a dicentric 22 by in situ hybridization
β Scribed by Vijay Tonk; Peter Osella; Antonio Delasmorenas; Herman E. Wyandt; Aubrey Milunsky
- Book ID
- 119105531
- Publisher
- Elsevier Science
- Year
- 1992
- Tongue
- English
- Weight
- 336 KB
- Volume
- 64
- Category
- Article
- ISSN
- 0165-4608
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Meningioma is a common tumor of the meninges covering the central nervous system. Although generally a benign tumor, meningioma often recurs and is malignant in 5-10% of all cases. Loss of chromosome 22 loci, and specifically inactivation of the NF2 tumor suppressor gene, is considered one of severa
Cytogenetic and molecular genetic analyses have shown that a tumor-suppressor gene for human meningioma is located on the long arm of chromosome 22. Recently, somatic mutations of the NF2 gene have been identified in sporadic meningiomas. However, tumorigenesis of certain cases of meningioma cannot