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Abnormal medial prefrontal cortex connectivity and defective fear extinction in the presymptomatic G93A SOD1 mouse model of ALS

✍ Scribed by C. Sgobio; A. Trabalza; A. Spalloni; C. Zona; I. Carunchio; P. Longone; M. Ammassari-Teule


Book ID
111273172
Publisher
John Wiley and Sons
Year
2008
Tongue
English
Weight
355 KB
Volume
7
Category
Article
ISSN
1601-1848

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## Abstract Glutamate excitotoxicity is strongly implicated as a major contributing factor in motor neuron degeneration in amyotrophic lateral sclerosis (ALS). Excitotoxicity results from elevated intracellular calcium ion (Ca^2+^) levels, which in turn recruit cell death signaling pathways. Recent