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Aberrant methylation frequency of TNFRSF10C Promoter in pancreatic cancer cell lines

โœ Scribed by Hui-Hua Cai; Yue-Ming Sun; Yi Miao; Wen-Tao Gao; Quan Peng; Jie Yao; Han-Lin Zhao

Book ID
117792600
Publisher
Zhejiang University School of Medicine, China
Year
2011
Tongue
English
Weight
488 KB
Volume
10
Category
Article
ISSN
1499-3872

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โœ Sonata Jarmalaite; Annamaria Kannio; Sisko Anttila; Juozas R. Lazutka; Kirsti Hu ๐Ÿ“‚ Article ๐Ÿ“… 2003 ๐Ÿ› John Wiley and Sons ๐ŸŒ French โš– 128 KB

Hypermethylation of cytosines in CpG-rich islands of the promoter regions of regulatory genes has been discovered as a common mechanism of gene silencing during carcinogenesis. We analysed 64 primary lung carcinomas for promoter methylation of the tumour suppressor genes (TSGs) p16 (p16(INK4a)/CDKN2